TITLE: Polyamine-Anthracene Conjugates: the Correlation between Interaction with DNA, PAT Activity, and Cytotoxicity
نویسنده
چکیده
Method: Using UV-visible spectroscopy, each Ant was compared based on the range of absorbance values it produced at increasing amounts of DNA until each reached the saturation point. The DNA binding data were then compared to the cytotoxicity level (IC50) of each Ant in two cell lines, CHO (Chinese hamster ovary) and CHO-MG (mutated cell line, no PAT). This enabled us to compare the cytotoxicity level of each Ant to DNA binding and PAT activity.
منابع مشابه
Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites.
Anthracene-polyamine conjugates inhibit the in vitro proliferation of the intraerythrocytic human malaria parasite Plasmodium falciparum, with 50% inhibitory concentrations (IC50s) in the nM to μM range. The compounds are taken up into the intraerythrocytic parasite, where they arrest the parasite cell cycle. Both the anthracene and polyamine components of the conjugates play a role in their an...
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